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April 12,2004 Germantown, WI USA: Cambridge Major Laboratories announces the appointment of University of California, Santa Barbara Professor Bruce Lipshutz as Scientific Advisor. Professor Lipshutz’ expertise in organometallics, nonracemic biaryl constructions, asymmetric catalysis, and heterocyclic chemistries will play a vital role in advancing Cambridge Major’s development of a wide range of key intermediates for use in Active Pharmaceutical Ingredients.

Professor Lipshutz’ research focuses on constructions of complex, highly functionalized biaryls, such as those found in the anti-AIDS michellamines and the clinically useful antibiotic vancomycin. His group also focuses on development of modular routes to substituted "cyclo-BINOLs" and related ligands in the "cyclo-NOBIN" and"cyclo-BINAP" series for use in asymmetric synthesis. In addition, development of the chemistry of the heterogeneous catalyst nickel-on-charcoal (Ni/C) is being further pursued for cross-coupling reactions, which holds promise for use in several contexts where the cost of palladium is an issue and where removal of soluble metal impurities is problematic. Also, recently disclosed was a new benchmark method for effecting asymmetric hydrosilylations of aryl ketones and imines using CuH chelated by the nonracemic ligands, such as Roche’s 3,5-xyl-MeO-BIPHEP and Takasago’s DTBM-SEGPHOS..

“We are excited to have Professor Lipshutz join our Scientific Advisory Team. His expertise will significantly help us to expedite synthesis of a wide range of pharmacologically active substances and their key intermediates”, said Dr. Michael Major, President and CEO of Cambridge Major. “Further, his knowledge and understanding in the pharmaceutical and biotech industries will help us in targeting key compounds that will have real and immediate need in those sectors. The addition of Professor Lipshutz underscores our commitment to scientific excellence, and also our desire to provide our customers innovative and highly relevant chemistry that works.”

Professor Lipshutz arrived at UC Santa Barbara in 1979 after completing a two-year American Cancer Society postdoctoral fellowship at Harvard University. He received his Ph.D. from Yale University. Dr. Lipshutz is the recipient of several honors and awards including: Alfred P. Sloan Fellowship, Camille and Henry Dreyfus Teacher-Scholar Award, a UCSB Plous Memorial Teaching Award, ACS Cope Scholar Award, and a UCSB Foundation Distinguished Faculty Teaching Award.

“I am honored to be part of this dynamic and talented team that exists at Cambridge Major” states Lipshutz, who is anxious to contribute to finding solutions to the challenging synthetic problems facing the pharma industry today, and tomorrow.

Cambridge Major Laboratories, Inc. is a service-based chemistry outsourcing partner to the world’s leading pharmaceutical and biotechnology companies, producing pharmaceutical intermediates, API’s, and other fine organic chemicals. Specializing in chemical process development and advanced multi-step organic synthesis, the Company operates two facilities near Milwaukee, Wisconsin including process chemistry laboratories, kilo labs, a pilot plant, and complete analytical laboratories. The Company has been FDA inspected and approved for cGMP manufacturing. Visit us at www.cambridgemajorlabs.com.

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