About Cambridge Major Laboratories

Cambridge Major Laboratories, Inc. (CML) is a leading global chemistry outsourcing partner to the pharmaceutical and biotechnology industries. Cambridge Major produces pharmaceutical intermediates and Active Pharmaceutical Ingredients (API), from early preclinical development to commercial manufacture.

Company Description

As a leader in advanced chemistry services, Cambridge Major boasts an impeccable reputation for delivering some of the most challenging projects, while meeting the tightest timelines. Cambridge Major’s reach is truly global. Operating three facilities in the U.S. and Europe, Cambridge Major is organized by five key integrated Centers of Excellence; Process chemistry, API Manufacturing, Analytical Sciences, Solid State Chemistry and Quality Assurance.

Solid State Chemistry and Crystallization center

CRYSTALLIZATION AND SOLID STATE CHEMISTRY SERVICES

Salt Selection and Polymorph studies Cambridge Major Laboratories (CML) has established a new Center of Excellence for Crystallization and Solid State Chemistry in our Active Pharmaceutical Ingredient (API) development facilities in the Netherlands. Significant investments have been made in equipment and personnel as part of Cambridge Major's expansion into solid state chemistry.

Cambridge Major's Solid State Chemistry Services

Crystallization Study – crystallize to obtain stable solids, for purification or isolation
Material Characterization – polymorph identification
Solubility Determination – in production solvents and buffer solutions
Salt Selection – suitable form selection
Polymorph Study – behavior in production solvents
Crystallization Process Development – combine optimal synthesis conditions with optimal crystallization conditions
Crystal Habit Optimization – control of particle size and shape

FormSelect™

FormSelect is the Cambridge Major approach to risk-mitigation in the early phases of API development. Polymorphic behavior and stability of a range of free form(s) and salts are studied in parallel, maximizing the chances of success.
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ProCryst™

ProCryst is the combination of Cambridge Major’s leading position in process chemistry with crystallization science to provide our clients the most optimal solutions ranging from polymorph studies to optimizing crystallization conditions along an entire synthetic pathway resulting in significant yield and cycle time improvements.
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Resources

Equipment List

Solid State Chemistry Presentation

SOLID STATE CHEMISTRY

From Discovery through commercial manufacture of active pharmaceutical ingredients – We Deliver

5 Centers of Excellence

Cambridge Major is organized along five key integrated Centers of Excellence, providing our clients with end-to-end solutions.

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Interested in having Cambridge Major quote on an upcoming project? Tell us more about your project goals and a member of our team will be in touch to discuss a potential partnership.