About Cambridge Major Laboratories

Cambridge Major Laboratories, Inc. (CML) is a leading global chemistry outsourcing partner to the pharmaceutical and biotechnology industries. Cambridge Major produces pharmaceutical intermediates and Active Pharmaceutical Ingredients (API), from early preclinical development to commercial manufacture.

Company Description

As a leader in advanced chemistry services, Cambridge Major boasts an impeccable reputation for delivering some of the most challenging projects, while meeting the tightest timelines. Cambridge Major’s reach is truly global. Operating three facilities in the U.S. and Europe, Cambridge Major is organized by five key integrated Centers of Excellence; Process chemistry, API Manufacturing, Analytical Sciences, Solid State Chemistry and Quality Assurance.

FormSelect™

drug substance and solid state chemistry Are you approaching candidate nomination? This is a key milestone in all drug development programs, and often directly linked to your next round of funding. Many times the HCl salt, or the free form of the molecule is taken as a default into toxicology studies. After all, this was what was generated in the medicinal chemistry phase. Unfortunately, many compounds have been rejected due to suboptimal properties, whereas the choice of a different (salt) form might have improved solubility and stability considerably. Don’t let your next compound get rejected in early development due to sub-optimized form.

FormSelect is the Cambridge Major approach to risk-mitigation in the early development phase. Polymorphic behavior and stability of a range of free form(s) and salts are studied in parallel, maximizing your chances of success.

By using only pharmaceutically-acceptable counter ions and solvents, and applying only scalable crystallization methods, a directed experimental program will rapidly generate information to aid in the selection of a “developable” form of your API.

CML employs state-of-the-art crystallization tools and highly experienced experts in drug substance solid state chemistry to drive your program. Make the right choice with FormSelect!

Resources

Solid State Presentation

FormSelect Decision Tree

SOLID STATE CHEMISTRY

From Discovery through commercial manufacture of active pharmaceutical ingredients – We Deliver

5 Centers of Excellence

Cambridge Major is organized along five key integrated Centers of Excellence, providing our clients with end-to-end solutions.

Request a Quote

Interested in having Cambridge Major quote on an upcoming project? Tell us more about your project goals and a member of our team will be in touch to discuss a potential partnership.